Development of Hydrogels and Biomimetic Regulators as Tissue Engineering Scaffolds

نویسندگان

  • Junbin Shi
  • Malcolm M. Q. Xing
  • Wen Zhong
چکیده

This paper reviews major research and development issues relating to hydrogels as scaffolds for tissue engineering, the article starts with a brief introduction of tissue engineering and hydrogels as extracellular matrix mimics, followed by a description of the various types of hydrogels and preparation methods, before a discussion of the physical and chemical properties that are important to their application. There follows a short comment on the trends of future research and development. Throughout the discussion there is an emphasis on the genetic understanding of bone tissue engineering application.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering.

A sacrificial templating process using lithographically printed minimal surface structures allows complex de novo geo-metries of delicate hydrogel materials. The hydrogel scaffolds based on cellulose and chitin nanofibrils show differences in terms of attachment of human mesenchymal stem cells, and allow their differentiation into osteogenic outcomes. The approach here serves as a first example...

متن کامل

Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering

Three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering because of their nanoscaled architecture, eg, nanofibers and nanopores, similar to the native extracellular matrix. In the conventional "top-down" approach, cells are seeded onto a biocompatible and biodegradable scaffold, in which cells are expected to populate in the scaffold and create their ...

متن کامل

Operative Dentistry and Biomaterials for Tooth Regenration

Tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. Replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. In each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. Scaffolds can be produced synthetically or derived ...

متن کامل

Tissue mimetics: engineered hydrogel matrices provide biomimetic environments for cell growth.

T issue-engineered scaffolds were initially designed for implantation with the idea of growing tissues in vitro before transplantation. This spawned several decades of research, which is still active today, into highly porous polymeric scaffolds in which cells are seeded and expected to develop into tissue. Biomaterial matrices were designed to provide structured extracellular matrix (ECM) anal...

متن کامل

Development of Cell - laden Hydrogels with High Mechanical Strength for Tissue Engineering Applications

The development of materials with biomimetic mechanical and biological properties is of great interest for regenerative medicine applications. Hydrogels are a promising class of biomaterials due to several advantages, however, the mechanical weakness remains a critical challenge for applications as tissue scaffolds. Particularly, scaffolds for load-bearing tissues such as cartilage and bone nee...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2012